Enzyme therapy

http://www.wellness.com/reference/healthwellness/enzyme-therapy/

BACKGROUND
Enzyme therapy is the use of enzymes to treat deficiencies and other medical conditions in the body.

Enzymes help to digest food, break down toxins, cleanse the blood, strengthen the immune system, build protein into muscle, contract muscles, eliminate carbon dioxide from the lungs and reduce stress on the pancreas and other vital organs.

Bromelain is one of the most popular enzymes used in enzyme therapy. When taken with meals, bromelain may aid in the digestion of proteins. When taken on an empty stomach, it may act as an anti-inflammatory agent.

Trypsin, a proteolytic enzyme, is also used in enzyme therapy. When taken orally, it is often used for digestive enzyme supplementation, often in combination with lipase and amylase. It has also been combined with bromelain and rutin to treat osteoarthritis. Trypsin may be used topically to remove necrotic tissue and debris during wound and ulcer cleaning. Trypsin supplements are derived from fungi or bacterial sources, pancreas of livestock or from plant sources. It may be used to remove dead tissue cells that remain after trauma, infection or surgical procedures. This removal allows new skin or tissue cells to grow.

Chymotrypsin has been used orally to reduce inflammation and edema (swelling) associated with abscesses, ulcers, surgery or trauma. This enzyme is also used as an expectorant in asthma and other pulmonary diseases, and in reducing liver stress. Topically, it is used for inflammatory and infectious disorders. It can also be used as an inhalant, intramuscular injection or opthalmically. It has ingredients that are proteolytic, anti-inflammatory and antioxidant, which are all thought to reduce tissue destruction.

Pancreatic enzymes were reportedly first used to treat cancer in 1902 by John Beard, a Scottish scientist. In the 1920s, Dr. Edward Howell introduced enzyme therapy to the United States. Howell believed that by eating raw meat, people created an enzyme surplus, which resulted in better health and increased resistance to disease. German researchers later used enzyme therapy to treat patients with multiple sclerosis, cancer and viral infections. Some enzyme mixtures are still commonly used in several European countries.

DOSING/INTERACTIONS

Bromelain: Interactions have been noted with some antibiotics, blood pressure drugs, anti-cancer drugs, drugs that increase the risk of bleeding (like aspirin, anticoagulants or warfarin (Coumadin®)), anti-platelet drugs (like clopidogrel (Plavix®)), antidepressants, alcohol, non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen (Motrin® or Advil®) or naproxen (Naprosyn® or Aleve®), narcotics (like codeine), potato protein, soybeans, and herbs or supplements with similar effects.
Human studies suggest that bromelain may increase the absorption of some antibiotics, notably amoxicillin and tetracycline, and increase levels of these drugs in the body. Bromelain may increase the actions of the chemotherapy (anti-cancer) drugs 5-fluorouracil and vincristine, although reliable scientific research in this area is lacking. In theory, use of bromelain with blood pressure medications in the "ACE inhibitor" class such as captopril (Capoten®) or lisinopril (Zestril®) may cause larger drops in blood pressure than expected.
A typical dose for adults (18 years and older) is 80-1000 milligram tablets up to three times daily. Dosing for children is not determined.

Some experts suggest that bromelain may cause drowsiness or sedation, and may increase the amount of drowsiness caused by some drugs. Examples include benzodiazepines such as lorazepam (Ativan®) or diazepam (Valium®), barbiturates such as phenobarbital, narcotics such as codeine, some antidepressants, and alcohol. Caution is advised while driving or operating machinery.

Trypsin: According to current available literature, there are no well-documented interactions. However, this does not mean there are no associated risks. Oral dosage in the combination product Phlogenzym®, which contains rutin 100mg, trypsin 48mg, and bromelain 90mg, has been given as two tablets three times daily for osteoarthritis.

Chymotrypsin: This enzyme is contraindicated in ocular surgery cases involving congenital cataracts, high vitreous pressure and a gaping incisional wound, or if the patient is twenty years old or younger. Oral dosages in a 6:1 ratio (trypsin: chymostrypsin) in a combined amount of 100,000 units USP four times daily has been used to treat inflammation, edema, and respiratory secretions. The same ratio of 200,000 units USP has been used four times daily for ten days to treat burns.